____Evol & Dev 12(6)_________BioEssays 34(11)________Frontiers EvoDevo Topic



  • Héctor Castillo, Francisco Godoy, Clément Gilbert, Felipe Aguilera, Salvatore Spicuglia, Sylvain Marcellini. Architecture and evolutionary conservation of Xenopus tropicalis osteoblast-specific regulatory regions shed light on bone diseases and early skeletal evolution bioRxiv. Submitted to Review Commons!
  • Maxence Lanoizelet, Léo Michel, Ronan Lagadec, Hélène Mayeur, Lucile Guichard, Dany Séverac, Kyle Martin, Christophe Klopp, Sylvain Marcellini, Hector Castillo, Nicolas Pollet, Eva Candal, Mélanie Debiais-Thibaud, Catherine Boisvert, Bernard Billoud, Michael Schubert, Patrick Blader, Sylvie Mazan Analysis of a shark reveals ancient habenular asymmetries in gnathostomes and points to Wnt regulation as a driving force in their diversification. bioRxiv. Submitted to Nature Communications!


  • Leurs N,  Martinand-Mari C, Marcellini S and Debiais-Thibaud M. Parallel evolution of ameloblastic SCPP genes in bony and cartilaginous vertebrates. (2022) Molecular Biology and Evolution. Vol 39 (5), pp1-11. PubMed.
  • Martínez E, Marcellini S, Henríquez JP. Beyond vertebrates: the amphioxus as a relevant model system to explore the formation, organization, and regeneratin of neuromuscular synapses. (2022) Neural Regeneration Research. Vol 17, Issue 11, pp2425-2426. PubMed.
  • Muñoz-Montecinos C, Romero A, Sepúlveda V, Vira MA, Fehrmann-Cartes K , Marcellini S, AguileraF, Caprile T, Fuentes R. Turning the Curve Into Straight: Phenogenetics of the Spine Morphology and Coordinate Maintenance in the Zebrafish. (2022) Frontiers in Cellular and Developmental Biology. Vol 12, Article 788346. PubMed.


  • Romero A, Leurs N, Muñoz, D, Debiais-Thibaud M, Marcellini S. Divergent expression of SPARC, SPARC-L and SCPP genes during jawed vertebrate cartilage mineralization. (2021) Frontiers in Genetics. Vol 12, Article 788346. PubMed. Check out our EvoDevo Topic !


  • Debiais-Thibaud M, Simion P, Ventéo S, Muñoz, D, Marcellini S, Mazan, S, Haitina T. Skeletal mineralization in association with type X collagen expression is an ancestral feature of jawed vertebrates. (2019) Molecular Biology and Evolution. 36(10):2265-2276 PubMed.
  • Aldea D, Subirana L, Keime C, Meister L, Maeso I, Marcellini S, Gomez-Skarmeta JL, Bertrand S, and Escriva H. Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm. (2019) Nature Ecology & Evolution. 3(8):1233-1240 PubMed.


  • Toro-Tapia G, Villaseca S, Beyer A, Roycroft A, Marcellini S, Mayor R, and Torrejón M. The Ric-8A/Gα13/FAK signaling cascade controls focal adhesion formation during neural crest cell migration. (2018) Development. 154(22) PubMed.
  • Muñoz D, Castillo H, Henriquez JP, Marcellini S. Bone regeneration after traumatic skull injury in Xenopus tropicalis. (2018) Mechanisms of Development. 154(153-161) PubMed. Part of the MOD special issue “Developmental Biology in Latin America”, here!
  • Bermedo-García F, Ojeda J, Méndez-Olivos EE, Marcellini S, Larraín J, Henríquez JP. The neuromuscular junction of Xenopus tadpoles: revisiting a classical model of early synaptogenesis and regeneration. (2018) Mechanisms of Development. 154(91-97) PubMed. Part of the MOD special issue “Developmental Biology in Latin America”, here!
  • Enault S, Muñoz D, Simion P, Ventéo S, Sire JY, Marcellini S, Debiais-Thibaud M. Evolution of dental tissue mineralization: an analysis of the jawed vertebrate SPARC and SPARC-L families. (2018). BMC Evolutionary Biology. 18(1):127. PubMed.
  • Otarola G, Castillo H and Marcellini S. Aryl hydrocarbon receptor-based bioassays for dioxin detection: Thinking outside the box. (2018) Journal of Applied Toxicology. 38(4):437-449. PubMed.


  • Cervantes-Diaz F, Contreas P and Marcellini S. Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis. (2017) Development Genes & Evolution. 227(2):121-127. PubMed.
  • Marcellini S, González FA, Sarrazin AF, Pabón-Mora N, Benítez M, Piñeyro-Nelson A, Rezende GL, Maldonado E, Schneider PN, Grizante MB, da Fonseca RN, Vergara-Silva F, Suaza-Gaviria V, Zumajo-Cardona C, Zattara EE, Casasa S, Suárez-Baron H, Brown FD. Evolutionary developmental biology (Evo-Devo) research in Latin America (2017) Journal of Experimental Zoology Part B: Molecular and Developmental Evolution., 328(1-2):5-40. PubMed.


  • Marcellini S and Escrivà H. Editorial: Evolution of organismal form: from regulatory interactions to developmental processes and biological patterns. (2016) Frontiers in Genetics, Vol 7, Article 148. PubMed. Check out our EvoDevo Topic !
  • Fritz A, Bertin A, Hanna P, Nualart F, Marcellini S. A single chance to contact multiple targets: distinct osteocyte morphotypes shed light on the cellular mechanism ensuring the robust formation of osteocytic networks. (2016) Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 326(5):280-9. PubMed.


  • Enault S, Muñoz D, Silva W, Borday-Birraux V, Bonade M, Oulion S, Ventéo S, Marcellini S, Debiais-Thibaud M. Molecular footprinting of skeletal tissues in the catshark Scyliorhinus canicula and the clawed frog Xenopus tropicalis identifies conserved and derived features of vertebrate calcification. (2015) Frontiers in Genetics, Volume6|Article283. This publication is part of an EvoDevo Topic !
  • Bertin A, Hanna P, Otarola G, Fritz A, Henriquez JP, Marcellini S. Cellular and molecular characterization of a novel primary osteoblast culture from the vertebrate model organism Xenopus tropicalis. (2015) Histochemistry and Cell Biology,143(4):431-42. PubMed.


  • Bertrand S, Fuentealba J, Aze A, Hudson C, Yasuo H, Torrejon M, Escriva H, Marcellini S. A dynamic history of  gene duplications and losses characterizes the evolution of the SPARC family in eumetazoans. (2013) Proceedings of the Royal Society B: Biological Sciences, 280(1757), 20122963. PubMed.
  • Aldea D, Hanna P, Munoz D, Espinoza J, Torrejon M, Sachs L, Buisine N, Oulion S, Escriva H, Marcellini S. Evolution of the vertebrate bone matrix: an expression analysis of the network forming collagen paralogues in amphibian osteoblasts. (2013) Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 320(6):375-84. PubMed.
  • Fuentealba J, Toro-Tapia G, Arriagada C, Riquelme L, Henriquez JP, Caprile T, Mayor R, Marcellini S, Hinrichs MV, Olate J, Torrejon M. Ric-8A, a Guanine Nucleotide Exchange Factor for Heterotrimeric G proteins, is critical for Cranial Neural Crest cell migration. (2013) Developmental Biology, 378(2):74-82. PubMed.
  • Sandoval D, Ojeda J, Low M, Nualart F, Marcellini S, Osses N, Henríquez JP. The vitamin C transporter SVCT2 is down-regulated during postnatal development of slow skeletal muscles. (2013) Histochemistry and Cell Biology, 139 (6), 887-94. PubMed.
  • Vera A, Stanic K, Montecinos H, Torrejon M, Marcellini S, Caprile T. SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development. (2013) Frontiers in Cellular Neuroscience., 7 (80). PubMed.



  • Espinoza J, Sanchez M, Sanchez A, Hanna P, Torrejon M, Buisine N, Sachs L, and Marcellini S. Two families of Xenopus tropicalis skeletal genes display well-conserved expression patterns with mammals in spite of their highly divergent regulatory regions. (2010) Evolution & Development, 12 (6), 541-51. PubMed. A picture from the LADE was selected for the cover!
  • Marcellini S, Bruna C, Henríquez JP, Albistur M, Reyes AE, Barriga EH, Henríquez B, Montecino M. Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. (2010) BMC Evol Biol. 10:78. PubMed


  • Montecino M, Stein G, Stein J, Lian J, van Wijnen A, Carvallo L, Marcellini S, Cruzat F and Arriagada G. Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery. (2008) Critical Reviews in Eukaryotic Gene Expression, 18(2), 163-72. PubMed


  • Bielen H, Oberleitner S, Marcellini S, Gee L, Lemaire P, Bode H, Rupp R, and Technau U. Divergent functions of two ancient Hydra Brachyury paralogs suggest specific roles for their C-terminal domains in tissue fate inductions. (2007) Development, 134(23), 4187-97. PubMed
  • Montecino M, Stein J, Stein G, Lian J, van Wijnen A, Cruzat F, Gutierrez S, Olate J, Marcellini S and Gutiérrez J. Nucleosome organization and targeting of ATP-dependent chromatin remodeling complexes: contributions of the DNA sequence. (2007) Biochemistry and Cell Biology, 85(4):419-25. PubMed
  • Montecino M, Stein GS, Cruzat F, Marcellini S, Stein JL, Lian JB, van Wijnen AJ, Arriagada G. An architectural perspective of vitamin D responsiveness. (2007) Archives of Biochemistry and Biophysics, 460(2):293-299. PubMed


  • Marcellini S. and Simpson P. Two or four bristles: functional evolution of an enhancer of scute in drosophilids. (2006) PLoS Biology, 4(12): e386. PubMed. Read the comment in PLoS Biology!Recommended by the FACULTY of 1000!
  • Simpson P. and Marcellini S. The origin and evolution of stereotyped patterns of macrochaetes on the nota of cyclorrapous Diptera. (2006) Heredity, 97(3):148-56. PubMed
  • Marcellini S. Evolution of bilaterian gastrulation: when Brachyury meets Smad1. (2006) BioEssays, 28(4):413-20. PubMed


  • Gibert JM, Marcellini S, Jean R. David Christian Schlötterer and Simpson P. A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor Poils-au-dos, a repressor of achaete-scute. (2005) Developmental Biology, 288(1):194-205. PubMed
  • Marcellini S, Gibert JM and Simpson P. achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila. (2005) Developmental Biology, 285(2):545-53. PubMed


  • Marcellini S, Technau U, Smith JC, Lemaire P. Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. (2003) Developmental Biology, 260(2):352-61. PubMedRecommended by the FACULTY of 1000!
  • Lemaire P and Marcellini S. Early animal embryogenesis: why so much variability? (2003) Biologist, 50(3):136-140. PDF




Bertrand S, Fuentealba J, Aze A, Hudson C, Yasuo H, Torrejon M, Escriva H, Marcellini S

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